The trifluoromethyl anion rapidly decomposes into difluorocarbene (:CF₂) and fluorine ion, limiting its applicability in synthesis. Here, the authors report a strategy to generate and use the short-lived CF₃- intermediate from stable CF₃H gas via fast biphasic mixing in precisely customized flow dissolvers.

Porous anisotropic nanohybrids have attracted attention because of their unique properties including high surface area, tunable pore structures and controllable compositions. Here, authors report a selective occupation strategy to achieve site-specific anisotropic growth of amorphous mesoporous subunits on crystalline MOFs.

It remains unclear how cells respond to complex extracellular geometries at the mesoscale. Here, the authors study the organization of bone cells in landscapes with varying curvatures, observing a preference for local concavities, multicellular bridging, and collective stress fiber orientation.

How primordial cells could achieve inheritance of encapsulated components is still an open question. Here, the authors show that ribozymes can assemble in active forms and replicate in populations of membrane vesicles thanks to freeze-thaw cycles.

Undercoordinated metal sites with well-defined structures and stability are desired properties for catalysts. Here, the authors construct a class of inorganic-organic hybrid electrocatalysts with enzyme-like properties, which exhibit enhanced electrochemical oxidation of 25 different organics.

This study constructs a new high-resolution 3D shear velocity model of the Australian continent using an extensive seismic dataset and a new imaging workflow, revealing detailed crustal structures that shed light on undercover mineral exploration.

Heterogeneous shock impedances of planetary materials cause abrupt changes of ejection angles, forming non-radial ejecta. Interpretations for provenances of surface deposits and ages derived from crater counts are affected by such untrackable ejecta.

When soil moisture is within the transitional regime that is neither too dry nor too wet, its variation affects evaporation and thus climate. This study shows that, under global warming, more areas will experience a transitional regime.

This study discovered non-monotonic variations in river flows for seven rivers originating from the Tibetan Plateau at warming levels of 1.5 °C, 2.0 °C, and 3.0 °C, which then resulted in different consequences for riparian countries

Magnesium Oxide and water are abundant in the interior of planets. Here, the authors predict three new MgO-H₂O compounds: Mg₂O₃H₂, MgO₃H₄ and MgO₄H₆, and they exhibit superionic behavior in planetary interior conditions.

In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.

How primordial cells could achieve inheritance of encapsulated components is still an open question. Here, the authors show that ribozymes can assemble in active forms and replicate in populations of membrane vesicles thanks to freeze-thaw cycles.

Hymenoptera is an incredibly diverse order, with numerous behavioral and morphological innovations. Here, the authors compile a time-calibrated Hymenoptera phylogeny and find that secondary transitions to phytophagy, plant feeding, are associated with significant increases in diversification rate in this group.

How histone H2A monoubiquitination (H2Aub1) is established at specific genomic locations remains unclear. Here, the authors report that Arabidopsis cohesin subunits SCC3 and SYN4 are involved in H2Aub1 through their direct or indirect interaction with BMI1A/B/C subunits of PRC1, the E3 ligases in PRC1 for H2Aub1.

X-ray diffraction images contain a signal that is an untapped source of information on protein dynamics. Here, the authors lay out a general workflow for interpreting this diffuse scattering signal and expanding the capabilities of protein crystallography.

Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph nodes to release IL-33, thereby mediating cold-induced beiging of WAT.

CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.

Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where they activate the PKReIF2α axis and terminate translation.

B7-H3 is expressed at high levels in several cancer types and can suppress antitumor immune responses. Here the authors show that B7-H3 expression is dependent on mTORC1 activity and that inhibition of B7-H3 promotes antitumor immunity mediated by cytolytic CD4 + T cells in tumor models with mTORC1 hyperactivity.

Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distinguish it from alternative causes of liver injury.

This paper shows that desertification combating practices decline incomes of farmers and herders, and China needs to adapt its ecological programmes to address the impacts of climate change and create positive synergies to combat desertification.

Smart membranes with responsive wettability show promise for controllably separating oil/water mixtures but it remains challenging to fabricate responsive and stable scalable membranes. Here, the authors develop a capillary force-driven self-assembling strategy to construct a scalable and stable CO2-responsive membrane for the smart separation of various oil/water systems.

This study finds that optimal global pooling generally provides greater financial resilience than optimal regional pooling and that both can significantly increase the risk diversification of the existing sovereign catastrophe risk pools.

Physical distancing measures introduced to control the spread of COVID-19 had socio-economic trade-offs that may have particularly impacted vulnerable population groups. Here, the authors perform a scoping review and summarise the impacts on different vulnerable groups described in 265 studies.

Here, using longitudinal survey and Twitter data, the authors examine the relationship between exposure to Russian Internet Research Agency activities on Twitter and voting behavior and attitudes in the 2016 US election.