matplotlib 2.0b4, ipython 5.1.0, python 3.5.2.
After calling plt.rcdefaults() in an ipython session, plotting commands (e.g. plt.plot([1, 2])) do not auto-show/auto-redraw the figure anymore (explicit calls to plt.show()/fig.canvas.draw() becomes needed). It would certainly be better if the auto-show/auto-redraw behavior was kept.